ICD-10-CM Book 2024 Edition

Chapters  /  Chapter 18  /  R50-R69  /  R65
R65 Symptoms and signs specifically associated with systemic inflammation and infection
R65.1 Systemic inflammatory response syndrome (SIRS) of non-infectious origin
CodeFirst underlying condition, such as:
heatstroke (T67.0-)
injury and trauma (S00-T88)
Excludes1 sepsis- code to infection
severe sepsis (R65.2)
R65.10 Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
Systemic inflammatory response syndrome (SIRS) NOS
nonPrimary Yes
R65.11 Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
UseAdditionalCode code to identify specific acute organ dysfunction, such as:
acute kidney failure (N17.-)
acute respiratory failure (J96.0-)
critical illness myopathy (G72.81)
critical illness polyneuropathy (G62.81)
disseminated intravascular coagulopathy [DIC] (D65)
encephalopathy (metabolic) (septic) (G93.41)
hepatic failure (K72.0-)
nonPrimary Yes
R65.2 Severe sepsis
Infection with associated acute organ dysfunction
Sepsis with acute organ dysfunction
Sepsis with multiple organ dysfunction
Systemic inflammatory response syndrome due to infectious process with acute organ dysfunction
CodeFirst underlying infection, such as:
infection following a procedure (T81.4-)
infections following infusion, transfusion and therapeutic injection (T80.2-)
puerperal sepsis (O85)
sepsis following complete or unspecified spontaneous abortion (O03.87)
sepsis following ectopic and molar pregnancy (O08.82)
sepsis following incomplete spontaneous abortion (O03.37)
sepsis following (induced) termination of pregnancy (O04.87)
sepsis NOS (A41.9)
UseAdditionalCode code to identify specific acute organ dysfunction, such as:
acute kidney failure (N17.-)
acute respiratory failure (J96.0-)
critical illness myopathy (G72.81)
critical illness polyneuropathy (G62.81)
disseminated intravascular coagulopathy [DIC] (D65)
encephalopathy (metabolic) (septic) (G93.41)
hepatic failure (K72.0-)
R65.20 Severe sepsis without septic shock
Severe sepsis NOS
nonPrimary Yes
R65.21 Severe sepsis with septic shock
nonPrimary Yes