D57 | 
		  | 
		Sickle-cell disorders   | 
	
	
		 |  | 
		
	
		| UseAdditionalCode | 
		code for any associated fever (R50.81)
  | 
	 
	
		| Excludes1 | 
		other hemoglobinopathies (D58.-)
  | 
	 
 
 | 
	
 |  | 
	
		 D57.0 | 
		  | 
		Hb-SS disease with crisis | 
	 
	
		 |  | 
		
| Sickle-cell disease with crisis |  | Hb-SS disease with (vaso-occlusive) pain |   
 | 
	  |  | 
	
		 D57.00 | 
		  | 
		Hb-SS disease with crisis, unspecified | 
	 
	
		 |  | 
		
| Hb-SS disease with (painful) crisis NOS |  | Hb-SS disease with (vaso-occlusive) pain NOS |   
 | 
	   |   |  | 
	
		 D57.01 | 
		 | 
		Hb-SS disease with acute chest syndrome | 
	 
  |   |  | 
	
		 D57.02 | 
		 | 
		Hb-SS disease with splenic sequestration | 
	 
  |   |  | 
	
		 D57.03 | 
		  | 
		Hb-SS disease with cerebral vascular involvement | 
	 
	
		 |  | 
		
	
		| CodeAlso | 
		, if applicable, cerebral infarction (I63.-)
  | 
	 
 
 | 
	   |   |  | 
	
		 D57.04 | 
		 | 
		Hb-SS disease with dactylitis | 
	 
  |   |  | 
	
		 D57.09 | 
		  | 
		Hb-SS disease with crisis with other specified complication | 
	 
	
		 |  | 
		
	
		| UseAdditionalCode | 
		code to identify complications, such as: cholelithiasis (K80.-) priapism (N48.32)
  | 
	 
 
 | 
	   |    | 
 |  | 
	
		 D57.1 | 
		  | 
		Sickle-cell disease without crisis | 
	 
	
		 |  | 
		
| Hb-SS disease without crisis |  | Sickle-cell anemia NOS |  | Sickle-cell disease NOS |  | Sickle-cell disorder NOS |   
 | 
	   | 
 |  | 
	
		 D57.2 | 
		  | 
		Sickle-cell/Hb-C disease | 
	 
	
		 |  | 
		
| Hb-SC disease |  | Hb-S/Hb-C disease |   
 | 
	  |  | 
	
		 D57.20 | 
		 | 
		Sickle-cell/Hb-C disease without crisis | 
	 
  |   |  | 
	
		 D57.21 | 
		 | 
		Sickle-cell/Hb-C disease with crisis | 
	 
 |  | 
	
		 D57.211 | 
		 | 
		Sickle-cell/Hb-C disease with acute chest syndrome | 
	 
  |   |  | 
	
		 D57.212 | 
		 | 
		Sickle-cell/Hb-C disease with splenic sequestration | 
	 
  |   |  | 
	
		 D57.213 | 
		  | 
		Sickle-cell/Hb-C disease with cerebral vascular involvement | 
	 
	
		 |  | 
		
	
		| CodeAlso | 
		, if applicable, cerebral infarction (I63.-)
  | 
	 
 
 | 
	   |   |  | 
	
		 D57.214 | 
		 | 
		Sickle-cell/Hb-C disease with dactylitis | 
	 
  |   |  | 
	
		 D57.218 | 
		  | 
		Sickle-cell/Hb-C disease with crisis with other specified complication | 
	 
	
		 |  | 
		
	
		| UseAdditionalCode | 
		code to identify complications, such as: cholelithiasis (K80.-) priapism (N48.32)
  | 
	 
 
 | 
	   |   |  | 
	
		 D57.219 | 
		  | 
		Sickle-cell/Hb-C disease with crisis, unspecified | 
	 
	
		 |  | 
		
| Sickle-cell/Hb-C disease with crisis NOS |  | Sickle-cell/Hb-C disease with (vaso-occlusive) pain NOS |   
 | 
	   |    |    | 
 |  | 
	
		 D57.3 | 
		  | 
		Sickle-cell trait | 
	 
	
		 |  | 
		
| Hb-S trait |  | Heterozygous hemoglobin S |   
 | 
	   | 
 |  | 
	
		 D57.4 | 
		  | 
		Sickle-cell thalassemia | 
	 
	
		 |  | 
		
| Sickle-cell beta thalassemia |  | Thalassemia Hb-S disease |   
 | 
	  |  | 
	
		 D57.40 | 
		  | 
		Sickle-cell thalassemia without crisis | 
	 
	
		 |  | 
		
| Microdrepanocytosis |  | Sickle-cell thalassemia NOS |   
 | 
	   |   |  | 
	
		 D57.41 | 
		  | 
		Sickle-cell thalassemia, unspecified, with crisis | 
	 
	
		 |  | 
		
| Sickle-cell thalassemia with (painful) crisis NOS |  | Sickle-cell thalassemia with (vaso-occlusive) pain NOS |   
 | 
	  |  | 
	
		 D57.411 | 
		 | 
		Sickle-cell thalassemia, unspecified, with acute chest syndrome | 
	 
  |   |  | 
	
		 D57.412 | 
		 | 
		Sickle-cell thalassemia, unspecified, with splenic sequestration | 
	 
  |   |  | 
	
		 D57.413 | 
		  | 
		Sickle-cell thalassemia, unspecified, with cerebral vascular involvement | 
	 
	
		 |  | 
		
	
		| CodeAlso | 
		, if applicable cerebral infarction (I63.-)
  | 
	 
 
 | 
	   |   |  | 
	
		 D57.414 | 
		 | 
		Sickle-cell thalassemia, unspecified, with dactylitis | 
	 
  |   |  | 
	
		 D57.418 | 
		  | 
		Sickle-cell thalassemia, unspecified, with crisis with other specified complication | 
	 
	
		 |  | 
		
	
		| UseAdditionalCode | 
		code to identify complications, such as: cholelithiasis (K80.-) priapism (N48.32)
  | 
	 
 
 | 
	   |   |  | 
	
		 D57.419 | 
		  | 
		Sickle-cell thalassemia, unspecified, with crisis | 
	 
	
		 |  | 
		
| Sickle-cell thalassemia with (painful) crisis NOS |  | Sickle-cell thalassemia with (vaso-occlusive) pain NOS |   
 | 
	   |    |   |  | 
	
		 D57.42 | 
		  | 
		Sickle-cell thalassemia beta zero without crisis | 
	 
	
		 |  | 
		
| HbS-beta zero without crisis |  | Sickle-cell beta zero without crisis |   
 | 
	   |   |  | 
	
		 D57.43 | 
		  | 
		Sickle-cell thalassemia beta zero with crisis | 
	 
	
		 |  | 
		
| HbS-beta zero with crisis |  | Sickle-cell beta zero with crisis |   
 | 
	  |  | 
	
		 D57.431 | 
		  | 
		Sickle-cell thalassemia beta zero with acute chest syndrome | 
	 
	
		 |  | 
		
| HbS-beta zero with acute chest syndrome |  | Sickle-cell beta zero with acute chest syndrome |   
 | 
	   |   |  | 
	
		 D57.432 | 
		  | 
		Sickle-cell thalassemia beta zero with splenic sequestration | 
	 
	
		 |  | 
		
| HbS-beta zero with splenic sequestration |  | Sickle-cell beta zero with splenic sequestration |   
 | 
	   |   |  | 
	
		 D57.433 | 
		  | 
		Sickle-cell thalassemia beta zero with cerebral vascular involvement | 
	 
	
		 |  | 
		
| HbS-beta zero with cerebral vascular involvement |  | Sickle-cell beta zero with cerebral vascular involvement |  	
		| CodeAlso | 
		, if applicable cerebral infarction (I63.-)
  | 
	 
 
 | 
	   |   |  | 
	
		 D57.434 | 
		 | 
		Sickle-cell thalassemia beta zero with dactylitis | 
	 
  |   |  | 
	
		 D57.438 | 
		  | 
		Sickle-cell thalassemia beta zero with crisis with other specified complication | 
	 
	
		 |  | 
		
| HbS-beta zero with other specified complication |  | Sickle-cell beta zero with other specified complication |  	
		| UseAdditionalCode | 
		code to identify complications, such as: cholelithiasis (K80.-) priapism (N48.32)
  | 
	 
 
 | 
	   |   |  | 
	
		 D57.439 | 
		  | 
		Sickle-cell thalassemia beta zero with crisis, unspecified | 
	 
	
		 |  | 
		
| HbS-beta zero with other specified complication |  | Sickle-cell beta zero with crisis unspecified |  | Sickle-cell thalassemia beta zero with (painful) crisis NOS |  | Sickle-cell thalassemia beta zero with (vaso-occlusive) pain NOS |   
 | 
	   |    |   |  | 
	
		 D57.44 | 
		  | 
		Sickle-cell thalassemia beta plus without crisis | 
	 
	
		 |  | 
		
| HbS-beta plus without crisis |  | Sickle-cell beta plus without crisis |   
 | 
	   |   |  | 
	
		 D57.45 | 
		  | 
		Sickle-cell thalassemia beta plus with crisis | 
	 
	
		 |  | 
		
| HbS-beta plus with crisis |  | Sickle-cell beta plus with crisis |   
 | 
	  |  | 
	
		 D57.451 | 
		  | 
		Sickle-cell thalassemia beta plus with acute chest syndrome | 
	 
	
		 |  | 
		
| HbS-beta plus with acute chest syndrome |  | Sickle-cell beta plus with acute chest syndrome |   
 | 
	   |   |  | 
	
		 D57.452 | 
		  | 
		Sickle-cell thalassemia beta plus with splenic sequestration | 
	 
	
		 |  | 
		
| HbS-beta plus with splenic sequestration |  | Sickle-cell beta plus with splenic sequestration |   
 | 
	   |   |  | 
	
		 D57.453 | 
		  | 
		Sickle-cell thalassemia beta plus with cerebral vascular involvement | 
	 
	
		 |  | 
		
| HbS-beta plus with cerebral vascular involvement |  | Sickle-cell beta plus with cerebral vascular involvement |  	
		| CodeAlso | 
		, if applicable cerebral infarction (I63.-)
  | 
	 
 
 | 
	   |   |  | 
	
		 D57.454 | 
		 | 
		Sickle-cell thalassemia beta plus with dactylitis | 
	 
  |   |  | 
	
		 D57.458 | 
		  | 
		Sickle-cell thalassemia beta plus with crisis with other specified complication | 
	 
	
		 |  | 
		
| HbS-beta plus with crisis with other specified complication |  | Sickle-cell beta plus with crisis with other specified complication |  	
		| UseAdditionalCode | 
		code to identify complications, such as: cholelithiasis (K80.-) priapism (N48.32)
  | 
	 
 
 | 
	   |   |  | 
	
		 D57.459 | 
		  | 
		Sickle-cell thalassemia beta plus with crisis, unspecified | 
	 
	
		 |  | 
		
| HbS-beta plus with crisis with unspecified complication |  | Sickle-cell beta plus with crisis with unspecified complication |  | Sickle-cell thalassemia beta plus with (painful) crisis NOS |  | Sickle-cell thalassemia beta plus with (vaso-occlusive) pain NOS |   
 | 
	   |    |    | 
 |  | 
	
		 D57.8 | 
		  | 
		Other sickle-cell disorders | 
	 
	
		 |  | 
		
| Hb-SD disease |  | Hb-SE disease |   
 | 
	  |  | 
	
		 D57.80 | 
		 | 
		Other sickle-cell disorders without crisis | 
	 
  |   |  | 
	
		 D57.81 | 
		 | 
		Other sickle-cell disorders with crisis | 
	 
 |  | 
	
		 D57.811 | 
		 | 
		Other sickle-cell disorders with acute chest syndrome | 
	 
  |   |  | 
	
		 D57.812 | 
		 | 
		Other sickle-cell disorders with splenic sequestration | 
	 
  |   |  | 
	
		 D57.813 | 
		  | 
		Other sickle-cell disorders with cerebral vascular involvement | 
	 
	
		 |  | 
		
	
		| CodeAlso | 
		, if applicable: cerebral infarction (I63.-)
  | 
	 
 
 | 
	   |   |  | 
	
		 D57.814 | 
		 | 
		Other sickle-cell disorders with dactylitis | 
	 
  |   |  | 
	
		 D57.818 | 
		  | 
		Other sickle-cell disorders with crisis with other specified complication | 
	 
	
		 |  | 
		
	
		| UseAdditionalCode | 
		code to identify complications, such as: cholelithiasis (K80.-) priapism (N48.32)
  | 
	 
 
 | 
	   |   |  | 
	
		 D57.819 | 
		  | 
		Other sickle-cell disorders with crisis, unspecified | 
	 
	
		 |  | 
		
| Other sickle-cell disorders with crisis NOS |  | Other sickle-cell disorders with (vaso-occlusive) pain NOS |   
 | 
	   |    |    |