D59 | 
		 | 
		Acquired hemolytic anemia   | 
	
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		 D59.0 | 
		  | 
		Drug-induced autoimmune hemolytic anemia | 
	 
	
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		| UseAdditionalCode | 
		code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  | 
	 
 
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		 D59.1 | 
		  | 
		Other autoimmune hemolytic anemias | 
	 
	
		 |  | 
		
	
		| Excludes2 | 
		Evans syndrome (D69.41) hemolytic disease of newborn (P55.-) paroxysmal cold hemoglobinuria (D59.6)
  | 
	 
 
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	  |  | 
	
		 D59.10 | 
		 | 
		Autoimmune hemolytic anemia, unspecified | 
	 
  |   |  | 
	
		 D59.11 | 
		  | 
		Warm autoimmune hemolytic anemia | 
	 
	
		 |  | 
		
| Warm type (primary) (secondary) (symptomatic) autoimmune hemolytic anemia |  | Warm type autoimmune hemolytic disease |   
 | 
	   |   |  | 
	
		 D59.12 | 
		  | 
		Cold autoimmune hemolytic anemia | 
	 
	
		 |  | 
		
| Chronic cold hemagglutinin disease |  | Cold agglutinin disease |  | Cold agglutinin hemoglobinuria |  | Cold type (primary) (secondary) (symptomatic) autoimmune hemolytic anemia |  | Cold type autoimmune hemolytic disease |   
 | 
	   |   |  | 
	
		 D59.13 | 
		  | 
		Mixed type autoimmune hemolytic anemia | 
	 
	
		 |  | 
		
| Mixed type autoimmune hemolytic disease |  | Mixed type, cold and warm, (primary) (secondary) (symptomatic) autoimmune hemolytic anemia |   
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	   |   |  | 
	
		 D59.19 | 
		 | 
		Other autoimmune hemolytic anemia | 
	 
  |    | 
 |  | 
	
		 D59.2 | 
		  | 
		Drug-induced nonautoimmune hemolytic anemia | 
	 
	
		 |  | 
		
| Drug-induced enzyme deficiency anemia |  	
		| UseAdditionalCode | 
		code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  | 
	 
 
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	   | 
 |  | 
	
		 D59.3 | 
		  | 
		Hemolytic-uremic syndrome | 
	 
	
		 |  | 
		
	
		| CodeAlso | 
		, if applicable, any associated: acute kidney failure (N17.-) chronic kidney disease (N18.-)
  | 
	 
 
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		 D59.30 | 
		  | 
		Hemolytic-uremic syndrome, unspecified | 
	 
	
		 |  | 
		
| Hemolytic-uremic syndrome NOS |   
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	   |   |  | 
	
		 D59.31 | 
		  | 
		Infection-associated hemolytic-uremic syndrome | 
	 
	
		 |  | 
		
| Shiga toxin-producing E. coli [STEC] related hemolytic uremic syndrome |  | Typical hemolytic uremic syndrome |  	
		| UseAdditionalCode | 
		code to identify associated infection, such as : E. coli infection (B96.2-) Human immunodeficiency virus [HIV] disease (B20) Pneumococcal meningitis (G00.1) Pneumococcal pneumonia (J13) Sepsis due to Streptococcus pneumoniae (A40.3) Shigella dysenteriae (A03.9) Streptococcus pneumoniae as the cause of diseases classified elsewhere (B95.3)
  | 
	 
 
 | 
	   |   |  | 
	
		 D59.32 | 
		  | 
		Hereditary hemolytic-uremic syndrome | 
	 
	
		 |  | 
		
| Atypical hemolytic uremic syndrome with an identified genetic cause |  	
		| CodeAlso | 
		, if applicable: defects in the complement system (D84.1) methylmalonic acidemia (E71.120)
  | 
	 
 
 | 
	   |   |  | 
	
		 D59.39 | 
		  | 
		Other hemolytic-uremic syndrome | 
	 
	
		 |  | 
		
| Atypical (nongenetic) hemolytic uremic syndrome |  | Secondary hemolytic-uremic syndrome |  	
		| CodeFirst | 
		, if applicable, any associated: COVID-19 (U07.1) complications of kidney transplant (T86.1-) complications of heart transplant (T86.2-) complications of liver transplant (T86.4-)
  | 
	 
	
		| CodeAlso | 
		, if applicable, any associated condition, such as: hypertensive emergency (I16.1) malignant neoplasm (C00-C96) systemic lupus erythematosus (M32.-)
  | 
	 
	
		| UseAdditionalCode | 
		code, if applicable, for adverse effect to identify drug (T36-T50 with fifth or sixth character 5)
  | 
	 
 
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	   |    | 
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		 D59.4 | 
		  | 
		Other nonautoimmune hemolytic anemias | 
	 
	
		 |  | 
		
| Mechanical hemolytic anemia |  | Microangiopathic hemolytic anemia |  | Toxic hemolytic anemia |   
 | 
	   | 
 |  | 
	
		 D59.5 | 
		  | 
		Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] | 
	 
	
		 |  | 
		
	
		| Excludes1 | 
		hemoglobinuria NOS (R82.3)
  | 
	 
 
 | 
	   | 
 |  | 
	
		 D59.6 | 
		  | 
		Hemoglobinuria due to hemolysis from other external causes | 
	 
	
		 |  | 
		
| Hemoglobinuria from exertion |  | March hemoglobinuria |  | Paroxysmal cold hemoglobinuria |  	
		| UseAdditionalCode | 
		code (Chapter 20) to identify external cause
  | 
	 
	
		| Excludes1 | 
		hemoglobinuria NOS (R82.3)
  | 
	 
 
 | 
	   | 
 |  | 
	
		 D59.8 | 
		 | 
		Other acquired hemolytic anemias | 
	 
  | 
 |  | 
	
		 D59.9 | 
		  | 
		Acquired hemolytic anemia, unspecified | 
	 
	
		 |  | 
		
| Idiopathic hemolytic anemia, chronic |   
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	   |