ICD-10-CM Book 2024 Edition

Chapters  /  Chapter 3  /  D80-D89  /  D89
D89 Other disorders involving the immune mechanism, not elsewhere classified
Excludes1 hyperglobulinemia NOS (R77.1)
monoclonal gammopathy (of undetermined significance) (D47.2)
Excludes2 transplant failure and rejection (T86.-)
D89.0 Polyclonal hypergammaglobulinemia
Benign hypergammaglobulinemic purpura
Polyclonal gammopathy NOS
D89.1 Cryoglobulinemia
Cryoglobulinemic purpura
Cryoglobulinemic vasculitis
Essential cryoglobulinemia
Idiopathic cryoglobulinemia
Mixed cryoglobulinemia
Primary cryoglobulinemia
Secondary cryoglobulinemia
D89.2 Hypergammaglobulinemia, unspecified
D89.3 Immune reconstitution syndrome
Immune reconstitution inflammatory syndrome [IRIS]
UseAdditionalCode code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
D89.4 Mast cell activation syndrome and related disorders
Excludes1 aggressive systemic mastocytosis (C96.21)
congenital cutaneous mastocytosis (Q82.2)
(non-congenital) cutaneous mastocytosis (D47.01)
(indolent) systemic mastocytosis (D47.02)
malignant mast cell neoplasm (C96.2-)
malignant mastocytoma (C96.29)
mast cell leukemia (C94.3-)
mast cell sarcoma (C96.22)
mastocytoma NOS (D47.09)
other mast cell neoplasms of uncertain behavior (D47.09)
systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02)
D89.40 Mast cell activation, unspecified
Mast cell activation disorder, unspecified
Mast cell activation syndrome, NOS
D89.41 Monoclonal mast cell activation syndrome
D89.42 Idiopathic mast cell activation syndrome
D89.43 Secondary mast cell activation
Secondary mast cell activation syndrome
CodeAlso underlying etiology, if known
D89.44 Hereditary alpha tryptasemia
UseAdditionalCode code, if applicable, for:
allergy status, other than to drugs and biological substances (Z91.0-)
personal history of anaphylaxis (Z87.892)
D89.49 Other mast cell activation disorder
Other mast cell activation syndrome
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
D89.81 Graft-versus-host disease
CodeFirst underlying cause, such as:
complications of transplanted organs and tissue (T86.-)
complications of blood transfusion (T80.89)
UseAdditionalCode code to identify associated manifestations, such as:
desquamative dermatitis (L30.8)
diarrhea (R19.7)
elevated bilirubin (R17)
hair loss (L65.9)
D89.810 Acute graft-versus-host disease
nonPrimary Yes
D89.811 Chronic graft-versus-host disease
nonPrimary Yes
D89.812 Acute on chronic graft-versus-host disease
nonPrimary Yes
D89.813 Graft-versus-host disease, unspecified
nonPrimary Yes
D89.82 Autoimmune lymphoproliferative syndrome [ALPS]
D89.83 Cytokine release syndrome
CodeFirst underlying cause, such as:
complications following infusion, transfusion and therapeutic injection (T80.89-)
complications of transplanted organs and tissue (T86.-)
UseAdditionalCode code to identify associated manifestations
D89.831 Cytokine release syndrome, grade 1
D89.832 Cytokine release syndrome, grade 2
D89.833 Cytokine release syndrome, grade 3
D89.834 Cytokine release syndrome, grade 4
D89.835 Cytokine release syndrome, grade 5
D89.839 Cytokine release syndrome, grade unspecified
D89.84 IgG4-related disease
Immunoglobulin G4-related disease
D89.89 Other specified disorders involving the immune mechanism, not elsewhere classified
Excludes1 human immunodeficiency virus disease (B20)
D89.9 Disorder involving the immune mechanism, unspecified
Immune disease NOS