ICD-10-CM Book 2024 Edition

Chapters  /  Chapter 2  /  D37-D48

Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (D37-D48)

Excludes1: neoplasms of unspecified behavior (D49.-)
D37 Neoplasm of uncertain behavior of oral cavity and digestive organs
Excludes1 stromal tumors of uncertain behavior of digestive system (D48.1-)
D37.0 Neoplasm of uncertain behavior of lip, oral cavity and pharynx
Excludes1 neoplasm of uncertain behavior of aryepiglottic fold or interarytenoid fold, laryngeal aspect (D38.0)
neoplasm of uncertain behavior of epiglottis NOS (D38.0)
neoplasm of uncertain behavior of skin of lip (D48.5)
neoplasm of uncertain behavior of suprahyoid portion of epiglottis (D38.0)
D37.01 Neoplasm of uncertain behavior of lip
Neoplasm of uncertain behavior of vermilion border of lip
D37.02 Neoplasm of uncertain behavior of tongue
D37.03 Neoplasm of uncertain behavior of the major salivary glands
D37.030 Neoplasm of uncertain behavior of the parotid salivary glands
D37.031 Neoplasm of uncertain behavior of the sublingual salivary glands
D37.032 Neoplasm of uncertain behavior of the submandibular salivary glands
D37.039 Neoplasm of uncertain behavior of the major salivary glands, unspecified
D37.04 Neoplasm of uncertain behavior of the minor salivary glands
Neoplasm of uncertain behavior of submucosal salivary glands of lip
Neoplasm of uncertain behavior of submucosal salivary glands of cheek
Neoplasm of uncertain behavior of submucosal salivary glands of hard palate
Neoplasm of uncertain behavior of submucosal salivary glands of soft palate
D37.05 Neoplasm of uncertain behavior of pharynx
Neoplasm of uncertain behavior of aryepiglottic fold of pharynx NOS
Neoplasm of uncertain behavior of hypopharyngeal aspect of aryepiglottic fold of pharynx
Neoplasm of uncertain behavior of marginal zone of aryepiglottic fold of pharynx
D37.09 Neoplasm of uncertain behavior of other specified sites of the oral cavity
D37.1 Neoplasm of uncertain behavior of stomach
D37.2 Neoplasm of uncertain behavior of small intestine
D37.3 Neoplasm of uncertain behavior of appendix
D37.4 Neoplasm of uncertain behavior of colon
D37.5 Neoplasm of uncertain behavior of rectum
Neoplasm of uncertain behavior of rectosigmoid junction
D37.6 Neoplasm of uncertain behavior of liver, gallbladder and bile ducts
Neoplasm of uncertain behavior of ampulla of Vater
D37.8 Neoplasm of uncertain behavior of other specified digestive organs
Neoplasm of uncertain behavior of anal canal
Neoplasm of uncertain behavior of anal sphincter
Neoplasm of uncertain behavior of anus NOS
Neoplasm of uncertain behavior of esophagus
Neoplasm of uncertain behavior of intestine NOS
Neoplasm of uncertain behavior of pancreas
Excludes1 neoplasm of uncertain behavior of anal margin (D48.5)
neoplasm of uncertain behavior of anal skin (D48.5)
neoplasm of uncertain behavior of perianal skin (D48.5)
D37.9 Neoplasm of uncertain behavior of digestive organ, unspecified
D38 Neoplasm of uncertain behavior of middle ear and respiratory and intrathoracic organs
Excludes1 neoplasm of uncertain behavior of heart (D48.7)
D38.0 Neoplasm of uncertain behavior of larynx
Neoplasm of uncertain behavior of aryepiglottic fold or interarytenoid fold, laryngeal aspect
Neoplasm of uncertain behavior of epiglottis (suprahyoid portion)
Excludes1 neoplasm of uncertain behavior of aryepiglottic fold or interarytenoid fold NOS (D37.05)
neoplasm of uncertain behavior of hypopharyngeal aspect of aryepiglottic fold (D37.05)
neoplasm of uncertain behavior of marginal zone of aryepiglottic fold (D37.05)
D38.1 Neoplasm of uncertain behavior of trachea, bronchus and lung
D38.2 Neoplasm of uncertain behavior of pleura
D38.3 Neoplasm of uncertain behavior of mediastinum
D38.4 Neoplasm of uncertain behavior of thymus
D38.5 Neoplasm of uncertain behavior of other respiratory organs
Neoplasm of uncertain behavior of accessory sinuses
Neoplasm of uncertain behavior of cartilage of nose
Neoplasm of uncertain behavior of middle ear
Neoplasm of uncertain behavior of nasal cavities
Excludes1 neoplasm of uncertain behavior of ear (external) (skin) (D48.5)
neoplasm of uncertain behavior of nose NOS (D48.7)
neoplasm of uncertain behavior of skin of nose (D48.5)
D38.6 Neoplasm of uncertain behavior of respiratory organ, unspecified
D39 Neoplasm of uncertain behavior of female genital organs
D39.0 Neoplasm of uncertain behavior of uterus
sex Female
D39.1 Neoplasm of uncertain behavior of ovary
UseAdditionalCode code to identify any functional activity.
D39.10 Neoplasm of uncertain behavior of unspecified ovary
sex Female
D39.11 Neoplasm of uncertain behavior of right ovary
sex Female
D39.12 Neoplasm of uncertain behavior of left ovary
sex Female
D39.2 Neoplasm of uncertain behavior of placenta
Chorioadenoma destruens
Invasive hydatidiform mole
Malignant hydatidiform mole
Excludes1 hydatidiform mole NOS (O01.9)
sex Female
age Maternity: [12-55]
D39.8 Neoplasm of uncertain behavior of other specified female genital organs
Neoplasm of uncertain behavior of skin of female genital organs
sex Female
D39.9 Neoplasm of uncertain behavior of female genital organ, unspecified
sex Female
D40 Neoplasm of uncertain behavior of male genital organs
D40.0 Neoplasm of uncertain behavior of prostate
sex Male
D40.1 Neoplasm of uncertain behavior of testis
D40.10 Neoplasm of uncertain behavior of unspecified testis
sex Male
D40.11 Neoplasm of uncertain behavior of right testis
sex Male
D40.12 Neoplasm of uncertain behavior of left testis
sex Male
D40.8 Neoplasm of uncertain behavior of other specified male genital organs
Neoplasm of uncertain behavior of skin of male genital organs
sex Male
D40.9 Neoplasm of uncertain behavior of male genital organ, unspecified
sex Male
D41 Neoplasm of uncertain behavior of urinary organs
D41.0 Neoplasm of uncertain behavior of kidney
Excludes1 neoplasm of uncertain behavior of renal pelvis (D41.1-)
D41.00 Neoplasm of uncertain behavior of unspecified kidney
D41.01 Neoplasm of uncertain behavior of right kidney
D41.02 Neoplasm of uncertain behavior of left kidney
D41.1 Neoplasm of uncertain behavior of renal pelvis
D41.10 Neoplasm of uncertain behavior of unspecified renal pelvis
D41.11 Neoplasm of uncertain behavior of right renal pelvis
D41.12 Neoplasm of uncertain behavior of left renal pelvis
D41.2 Neoplasm of uncertain behavior of ureter
D41.20 Neoplasm of uncertain behavior of unspecified ureter
D41.21 Neoplasm of uncertain behavior of right ureter
D41.22 Neoplasm of uncertain behavior of left ureter
D41.3 Neoplasm of uncertain behavior of urethra
D41.4 Neoplasm of uncertain behavior of bladder
D41.8 Neoplasm of uncertain behavior of other specified urinary organs
D41.9 Neoplasm of uncertain behavior of unspecified urinary organ
D42 Neoplasm of uncertain behavior of meninges
D42.0 Neoplasm of uncertain behavior of cerebral meninges
D42.1 Neoplasm of uncertain behavior of spinal meninges
D42.9 Neoplasm of uncertain behavior of meninges, unspecified
D43 Neoplasm of uncertain behavior of brain and central nervous system
Excludes1 neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system (D48.2)
D43.0 Neoplasm of uncertain behavior of brain, supratentorial
Neoplasm of uncertain behavior of cerebral ventricle
Neoplasm of uncertain behavior of cerebrum
Neoplasm of uncertain behavior of frontal lobe
Neoplasm of uncertain behavior of occipital lobe
Neoplasm of uncertain behavior of parietal lobe
Neoplasm of uncertain behavior of temporal lobe
Excludes1 neoplasm of uncertain behavior of fourth ventricle (D43.1)
D43.1 Neoplasm of uncertain behavior of brain, infratentorial
Neoplasm of uncertain behavior of brain stem
Neoplasm of uncertain behavior of cerebellum
Neoplasm of uncertain behavior of fourth ventricle
D43.2 Neoplasm of uncertain behavior of brain, unspecified
D43.3 Neoplasm of uncertain behavior of cranial nerves
D43.4 Neoplasm of uncertain behavior of spinal cord
D43.8 Neoplasm of uncertain behavior of other specified parts of central nervous system
D43.9 Neoplasm of uncertain behavior of central nervous system, unspecified
Neoplasm of uncertain behavior of nervous system (central) NOS
D44 Neoplasm of uncertain behavior of endocrine glands
Excludes1 multiple endocrine adenomatosis (E31.2-)
multiple endocrine neoplasia (E31.2-)
neoplasm of uncertain behavior of endocrine pancreas (D37.8)
neoplasm of uncertain behavior of ovary (D39.1-)
neoplasm of uncertain behavior of testis (D40.1-)
neoplasm of uncertain behavior of thymus (D38.4)
D44.0 Neoplasm of uncertain behavior of thyroid gland
D44.1 Neoplasm of uncertain behavior of adrenal gland
UseAdditionalCode code to identify any functional activity.
D44.10 Neoplasm of uncertain behavior of unspecified adrenal gland
D44.11 Neoplasm of uncertain behavior of right adrenal gland
D44.12 Neoplasm of uncertain behavior of left adrenal gland
D44.2 Neoplasm of uncertain behavior of parathyroid gland
D44.3 Neoplasm of uncertain behavior of pituitary gland
UseAdditionalCode code to identify any functional activity.
D44.4 Neoplasm of uncertain behavior of craniopharyngeal duct
D44.5 Neoplasm of uncertain behavior of pineal gland
D44.6 Neoplasm of uncertain behavior of carotid body
D44.7 Neoplasm of uncertain behavior of aortic body and other paraganglia
D44.9 Neoplasm of uncertain behavior of unspecified endocrine gland
D45 Polycythemia vera
Excludes1 familial polycythemia (D75.0)
secondary polycythemia (D75.1)
D46 Myelodysplastic syndromes
UseAdditionalCode code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
Excludes2 drug-induced aplastic anemia (D61.1)
D46.0 Refractory anemia without ring sideroblasts, so stated
Refractory anemia without sideroblasts, without excess of blasts
D46.1 Refractory anemia with ring sideroblasts
RARS
D46.2 Refractory anemia with excess of blasts [RAEB]
D46.20 Refractory anemia with excess of blasts, unspecified
RAEB NOS
D46.21 Refractory anemia with excess of blasts 1
RAEB 1
D46.22 Refractory anemia with excess of blasts 2
RAEB 2
D46.A Refractory cytopenia with multilineage dysplasia
D46.B Refractory cytopenia with multilineage dysplasia and ring sideroblasts
RCMD RS
D46.C Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality
Myelodysplastic syndrome with 5q deletion
5q minus syndrome NOS
D46.4 Refractory anemia, unspecified
D46.Z Other myelodysplastic syndromes
Excludes1 chronic myelomonocytic leukemia (C93.1-)
D46.9 Myelodysplastic syndrome, unspecified
Myelodysplasia NOS
D47 Other neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue
D47.0 Mast cell neoplasms of uncertain behavior
Excludes1 congenital cutaneous mastocytosis (Q82.2)
histiocytic neoplasms of uncertain behavior (D47.Z9)
malignant mast cell neoplasm (C96.2-)
D47.01 Cutaneous mastocytosis
Diffuse cutaneous mastocytosis
Maculopapular cutaneous mastocytosis
Solitary mastocytoma
Telangiectasia macularis eruptiva perstans
Urticaria pigmentosa
Excludes1 congenital (diffuse) (maculopapular) cutaneous mastocytosis (Q82.2)
congenital urticaria pigmentosa (Q82.2)
extracutaneous mastocytoma (D47.09)
D47.02 Systemic mastocytosis
Indolent systemic mastocytosis
Isolated bone marrow mastocytosis
Smoldering systemic mastocytosis
Systemic mastocytosis, with an associated hematological non-mast cell lineage disease (SM-AHNMD)
CodeAlso , if applicable, any associated hematological non-mast cell lineage disease, such as:
acute myeloid leukemia (C92.6-, C92.A-)
chronic myelomonocytic leukemia (C93.1-)
essential thrombocytosis (D47.3)
hypereosinophilic syndrome (D72.1)
myelodysplastic syndrome (D46.9)
myeloproliferative syndrome (D47.1)
non-Hodgkin lymphoma (C82-C85)
plasma cell myeloma (C90.0-)
polycythemia vera (D45)
Excludes1 aggressive systemic mastocytosis (C96.21)
mast cell leukemia (C94.3-)
D47.09 Other mast cell neoplasms of uncertain behavior
Extracutaneous mastocytoma
Mast cell tumor NOS
Mastocytoma NOS
Mastocytosis NOS
D47.1 Chronic myeloproliferative disease
Chronic neutrophilic leukemia
Myeloproliferative disease, unspecified
Excludes1 atypical chronic myeloid leukemia BCR/ABL-negative (C92.2-)
chronic myeloid leukemia BCR/ABL-positive (C92.1-)
myelofibrosis NOS (D75.81)
myelophthisic anemia (D61.82)
myelophthisis (D61.82)
secondary myelofibrosis NOS (D75.81)
D47.2 Monoclonal gammopathy
Monoclonal gammopathy of undetermined significance [MGUS]
D47.3 Essential (hemorrhagic) thrombocythemia
Essential thrombocytosis
Idiopathic hemorrhagic thrombocythemia
Primary thrombocytosis
Excludes2 reactive thrombocytosis (D75.838)
secondary thrombocytosis (D75.838)
thrombocythemia NOS (D75.839)
thrombocytosis NOS (D75.839)
D47.4 Osteomyelofibrosis
Chronic idiopathic myelofibrosis
Myelofibrosis (idiopathic) (with myeloid metaplasia)
Myelosclerosis (megakaryocytic) with myeloid metaplasia
Secondary myelofibrosis in myeloproliferative disease
Excludes1 acute myelofibrosis (C94.4-)
D47.Z Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue
D47.Z1 Post-transplant lymphoproliferative disorder (PTLD)
CodeFirst complications of transplanted organs and tissue (T86.-)
nonPrimary Yes
D47.Z2 Castleman disease
CodeAlso , if applicable, human herpesvirus 8 infection (B10.89)
Excludes2 Kaposi's sarcoma (C46.-)
D47.Z9 Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue
Histiocytic tumors of uncertain behavior
D47.9 Neoplasm of uncertain behavior of lymphoid, hematopoietic and related tissue, unspecified
Lymphoproliferative disease NOS
D48 Neoplasm of uncertain behavior of other and unspecified sites
Excludes1 neurofibromatosis (nonmalignant) (Q85.0-)
D48.0 Neoplasm of uncertain behavior of bone and articular cartilage
Excludes1 neoplasm of uncertain behavior of cartilage of ear (D48.1-)
neoplasm of uncertain behavior of cartilage of larynx (D38.0)
neoplasm of uncertain behavior of cartilage of nose (D38.5)
neoplasm of uncertain behavior of connective tissue of eyelid (D48.1-)
neoplasm of uncertain behavior of synovia (D48.1-)
D48.1 Neoplasm of uncertain behavior of connective and other soft tissue
Neoplasm of uncertain behavior of connective tissue of ear
Neoplasm of uncertain behavior of connective tissue of eyelid
Stromal tumors of uncertain behavior of digestive system
Excludes1 neoplasm of uncertain behavior of articular cartilage (D48.0)
neoplasm of uncertain behavior of cartilage of larynx (D38.0)
neoplasm of uncertain behavior of cartilage of nose (D38.5)
neoplasm of uncertain behavior of connective tissue of breast (D48.6-)
D48.11 Desmoid tumor
D48.110 Desmoid tumor of head and neck
D48.111 Desmoid tumor of chest wall
D48.112 Desmoid tumor, intrathoracic
D48.113 Desmoid tumor of abdominal wall
D48.114 Desmoid tumor, intraabdominal
Desmoid tumor of pelvic cavity
Desmoid tumor, peritoneal, retroperitoneal
D48.115 Desmoid tumor of upper extremity and shoulder girdle
D48.116 Desmoid tumor of lower extremity and pelvic girdle
Desmoid tumor of buttock
D48.117 Desmoid tumor of back
D48.118 Desmoid tumor of other site
D48.119 Desmoid tumor of unspecified site
D48.19 Other specified neoplasm of uncertain behavior of connective and other soft tissue
D48.2 Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system
Excludes1 neoplasm of uncertain behavior of peripheral nerves of orbit (D48.7)
D48.3 Neoplasm of uncertain behavior of retroperitoneum
D48.4 Neoplasm of uncertain behavior of peritoneum
D48.5 Neoplasm of uncertain behavior of skin
Neoplasm of uncertain behavior of anal margin
Neoplasm of uncertain behavior of anal skin
Neoplasm of uncertain behavior of perianal skin
Neoplasm of uncertain behavior of skin of breast
Excludes1 neoplasm of uncertain behavior of anus NOS (D37.8)
neoplasm of uncertain behavior of skin of genital organs (D39.8, D40.8)
neoplasm of uncertain behavior of vermilion border of lip (D37.0)
D48.6 Neoplasm of uncertain behavior of breast
Neoplasm of uncertain behavior of connective tissue of breast
Cystosarcoma phyllodes
Excludes1 neoplasm of uncertain behavior of skin of breast (D48.5)
D48.60 Neoplasm of uncertain behavior of unspecified breast
D48.61 Neoplasm of uncertain behavior of right breast
D48.62 Neoplasm of uncertain behavior of left breast
D48.7 Neoplasm of uncertain behavior of other specified sites
Neoplasm of uncertain behavior of eye
Neoplasm of uncertain behavior of heart
Neoplasm of uncertain behavior of peripheral nerves of orbit
Excludes1 neoplasm of uncertain behavior of connective tissue (D48.1-)
neoplasm of uncertain behavior of skin of eyelid (D48.5)
D48.9 Neoplasm of uncertain behavior, unspecified