ICD-10-CM Book 2024 Edition

Chapters  /  Chapter 4  /  E20-E35

Disorders of other endocrine glands (E20-E35)

Excludes1: galactorrhea (N64.3)
gynecomastia (N62)
E20 Hypoparathyroidism
Excludes1 Di George's syndrome (D82.1)
postprocedural hypoparathyroidism (E89.2)
tetany NOS (R29.0)
transitory neonatal hypoparathyroidism (P71.4)
E20.0 Idiopathic hypoparathyroidism
E20.1 Pseudohypoparathyroidism
E20.8 Other hypoparathyroidism
E20.81 Hypoparathyroidism due to impaired parathyroid hormone secretion
E20.810 Autosomal dominant hypocalcemia
Autosomal dominant hypocalcemia type 1 (ADH1)
Autosomal dominant hypocalcemia type 2 (ADH2)
CodeAlso , if applicable, any associated conditions, such as:
calculus of kidney (N20.0)
chronic kidney disease (N18.-)
respiratory distress (J80, R06.-)
seizure disorder (G40.-, R56.9)
E20.811 Secondary hypoparathyroidism in diseases classified elsewhere
CodeFirst underlying condition, if known
E20.812 Autoimmune hypoparathyroidism
CodeFirst , if applicable, underlying condition such as:
autoimmune polyglandular failure (E31.0)
Schmidt's syndrome (E31.0)
E20.818 Other specified hypoparathyroidism due to impaired parathyroid hormone secretion
Familial isolated hypoparathyroidism
E20.819 Hypoparathyroidism due to impaired parathyroid hormone secretion, unspecified
E20.89 Other specified hypoparathyroidism
Familial hypoparathyroidism
E20.9 Hypoparathyroidism, unspecified
Parathyroid tetany
E21 Hyperparathyroidism and other disorders of parathyroid gland
Excludes1 adult osteomalacia (M83.-)
ectopic hyperparathyroidism (E34.2)
hungry bone syndrome (E83.81)
infantile and juvenile osteomalacia (E55.0)
Excludes2 familial hypocalciuric hypercalcemia (E83.52)
E21.0 Primary hyperparathyroidism
Hyperplasia of parathyroid
Osteitis fibrosa cystica generalisata [von Recklinghausen's disease of bone]
E21.1 Secondary hyperparathyroidism, not elsewhere classified
Excludes1 secondary hyperparathyroidism of renal origin (N25.81)
E21.2 Other hyperparathyroidism
Tertiary hyperparathyroidism
Excludes1 familial hypocalciuric hypercalcemia (E83.52)
E21.3 Hyperparathyroidism, unspecified
E21.4 Other specified disorders of parathyroid gland
E21.5 Disorder of parathyroid gland, unspecified
E22 Hyperfunction of pituitary gland
Excludes1 Cushing's syndrome (E24.-)
Nelson's syndrome (E24.1)
overproduction of ACTH not associated with Cushing's disease (E27.0)
overproduction of pituitary ACTH (E24.0)
overproduction of thyroid-stimulating hormone (E05.8-)
E22.0 Acromegaly and pituitary gigantism
Overproduction of growth hormone
Excludes1 constitutional gigantism (E34.4)
constitutional tall stature (E34.4)
increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8)
E22.1 Hyperprolactinemia
UseAdditionalCode code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
E22.8 Other hyperfunction of pituitary gland
Central precocious puberty
E22.9 Hyperfunction of pituitary gland, unspecified
E23 Hypofunction and other disorders of the pituitary gland
Includes the listed conditions whether the disorder is in the pituitary or the hypothalamus
Excludes1 postprocedural hypopituitarism (E89.3)
short stature due to endocrine disorder (E34.3-)
E23.0 Hypopituitarism
Fertile eunuch syndrome
Hypogonadotropic hypogonadism
Idiopathic growth hormone deficiency
Isolated deficiency of gonadotropin
Isolated deficiency of growth hormone
Isolated deficiency of pituitary hormone
Kallmann's syndrome
Lorain-Levi short stature
Necrosis of pituitary gland (postpartum)
Panhypopituitarism
Pituitary cachexia
Pituitary insufficiency NOS
Pituitary short stature
Sheehan's syndrome
Simmonds' disease
E23.1 Drug-induced hypopituitarism
UseAdditionalCode code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
E23.2 Diabetes insipidus
Excludes1 nephrogenic diabetes insipidus (N25.1)
E23.3 Hypothalamic dysfunction, not elsewhere classified
Excludes1 Prader-Willi syndrome (Q87.11)
Russell-Silver syndrome (Q87.19)
E23.6 Other disorders of pituitary gland
Abscess of pituitary
Adiposogenital dystrophy
E23.7 Disorder of pituitary gland, unspecified
E24 Cushing's syndrome
Excludes1 congenital adrenal hyperplasia (E25.0)
E24.0 Pituitary-dependent Cushing's disease
Overproduction of pituitary ACTH
Pituitary-dependent hypercorticalism
E24.1 Nelson's syndrome
E24.2 Drug-induced Cushing's syndrome
UseAdditionalCode code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
E24.3 Ectopic ACTH syndrome
E24.4 Alcohol-induced pseudo-Cushing's syndrome
E24.8 Other Cushing's syndrome
E24.9 Cushing's syndrome, unspecified
E25 Adrenogenital disorders
Includes adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesis
Female adrenal pseudohermaphroditism
Female heterosexual precocious pseudopuberty
Male isosexual precocious pseudopuberty
Male macrogenitosomia praecox
Male sexual precocity with adrenal hyperplasia
Male virilization (female)
Excludes1 indeterminate sex and pseudohermaphroditism (Q56)
chromosomal abnormalities (Q90-Q99)
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
Congenital adrenal hyperplasia
21-Hydroxylase deficiency
Salt-losing congenital adrenal hyperplasia
E25.8 Other adrenogenital disorders
Idiopathic adrenogenital disorder
UseAdditionalCode code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
E25.9 Adrenogenital disorder, unspecified
Adrenogenital syndrome NOS
E26 Hyperaldosteronism
E26.0 Primary hyperaldosteronism
E26.01 Conn's syndrome
CodeAlso adrenal adenoma (D35.0-)
E26.02 Glucocorticoid-remediable aldosteronism
Familial aldosteronism type I
E26.09 Other primary hyperaldosteronism
Primary aldosteronism due to adrenal hyperplasia (bilateral)
E26.1 Secondary hyperaldosteronism
E26.8 Other hyperaldosteronism
E26.81 Bartter's syndrome
E26.89 Other hyperaldosteronism
E26.9 Hyperaldosteronism, unspecified
Aldosteronism NOS
Hyperaldosteronism NOS
E27 Other disorders of adrenal gland
E27.0 Other adrenocortical overactivity
Overproduction of ACTH, not associated with Cushing's disease
Premature adrenarche
Excludes1 Cushing's syndrome (E24.-)
E27.1 Primary adrenocortical insufficiency
Addison's disease
Autoimmune adrenalitis
Excludes1 Addison only phenotype adrenoleukodystrophy (E71.528)
amyloidosis (E85.-)
tuberculous Addison's disease (A18.7)
Waterhouse-Friderichsen syndrome (A39.1)
E27.2 Addisonian crisis
Adrenal crisis
Adrenocortical crisis
E27.3 Drug-induced adrenocortical insufficiency
UseAdditionalCode code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
E27.4 Other and unspecified adrenocortical insufficiency
Excludes1 adrenoleukodystrophy [Addison-Schilder] (E71.528)
Waterhouse-Friderichsen syndrome (A39.1)
E27.40 Unspecified adrenocortical insufficiency
Adrenocortical insufficiency NOS
Hypoaldosteronism
E27.49 Other adrenocortical insufficiency
Adrenal hemorrhage
Adrenal infarction
E27.5 Adrenomedullary hyperfunction
Adrenomedullary hyperplasia
Catecholamine hypersecretion
E27.8 Other specified disorders of adrenal gland
Abnormality of cortisol-binding globulin
E27.9 Disorder of adrenal gland, unspecified
E28 Ovarian dysfunction
Excludes1 isolated gonadotropin deficiency (E23.0)
postprocedural ovarian failure (E89.4-)
E28.0 Estrogen excess
UseAdditionalCode code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
sex Female
E28.1 Androgen excess
Hypersecretion of ovarian androgens
UseAdditionalCode code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
sex Female
E28.2 Polycystic ovarian syndrome
Sclerocystic ovary syndrome
Stein-Leventhal syndrome
sex Female
E28.3 Primary ovarian failure
Excludes1 pure gonadal dysgenesis (Q99.1)
Turner's syndrome (Q96.-)
E28.31 Premature menopause
E28.310 Symptomatic premature menopause
Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with premature menopause
sex Female
age Adult: [15-124]
E28.319 Asymptomatic premature menopause
Premature menopause NOS
sex Female
age Adult: [15-124]
E28.39 Other primary ovarian failure
Decreased estrogen
Resistant ovary syndrome
sex Female
E28.8 Other ovarian dysfunction
Ovarian hyperfunction NOS
Excludes1 postprocedural ovarian failure (E89.4-)
sex Female
E28.9 Ovarian dysfunction, unspecified
sex Female
E29 Testicular dysfunction
Excludes1 androgen insensitivity syndrome (E34.5-)
azoospermia or oligospermia NOS (N46.0-N46.1)
isolated gonadotropin deficiency (E23.0)
Klinefelter's syndrome (Q98.0-Q98.1, Q98.4)
E29.0 Testicular hyperfunction
Hypersecretion of testicular hormones
sex Male
E29.1 Testicular hypofunction
Defective biosynthesis of testicular androgen NOS
5-delta-Reductase deficiency (with male pseudohermaphroditism)
Testicular hypogonadism NOS
UseAdditionalCode code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
Excludes1 postprocedural testicular hypofunction (E89.5)
sex Male
E29.8 Other testicular dysfunction
sex Male
E29.9 Testicular dysfunction, unspecified
sex Male
E30 Disorders of puberty, not elsewhere classified
E30.0 Delayed puberty
Constitutional delay of puberty
Delayed sexual development
E30.1 Precocious puberty
Precocious menstruation
Excludes1 Albright (-McCune) (-Sternberg) syndrome (Q78.1)
central precocious puberty (E22.8)
congenital adrenal hyperplasia (E25.0)
female heterosexual precocious pseudopuberty (E25.-)
male isosexual precocious pseudopuberty (E25.-)
age Pediatric: [0-17]
E30.8 Other disorders of puberty
Premature thelarche
age Pediatric: [0-17]
E30.9 Disorder of puberty, unspecified
E31 Polyglandular dysfunction
Excludes1 ataxia telangiectasia [Louis-Bar] (G11.3)
dystrophia myotonica [Steinert] (G71.11)
pseudohypoparathyroidism (E20.1)
E31.0 Autoimmune polyglandular failure
Schmidt's syndrome
E31.1 Polyglandular hyperfunction
Excludes1 multiple endocrine adenomatosis (E31.2-)
multiple endocrine neoplasia (E31.2-)
E31.2 Multiple endocrine neoplasia [MEN] syndromes
Multiple endocrine adenomatosis
CodeAlso any associated malignancies and other conditions associated with the syndromes
E31.20 Multiple endocrine neoplasia [MEN] syndrome, unspecified
Multiple endocrine adenomatosis NOS
Multiple endocrine neoplasia [MEN] syndrome NOS
E31.21 Multiple endocrine neoplasia [MEN] type I
Wermer's syndrome
E31.22 Multiple endocrine neoplasia [MEN] type IIA
Sipple's syndrome
E31.23 Multiple endocrine neoplasia [MEN] type IIB
E31.8 Other polyglandular dysfunction
E31.9 Polyglandular dysfunction, unspecified
E32 Diseases of thymus
Excludes1 aplasia or hypoplasia of thymus with immunodeficiency (D82.1)
myasthenia gravis (G70.0)
E32.0 Persistent hyperplasia of thymus
Hypertrophy of thymus
E32.1 Abscess of thymus
E32.8 Other diseases of thymus
Excludes1 aplasia or hypoplasia with immunodeficiency (D82.1)
thymoma (D15.0)
E32.9 Disease of thymus, unspecified
E34 Other endocrine disorders
Excludes1 pseudohypoparathyroidism (E20.1)
E34.0 Carcinoid syndrome
Notes May be used as an additional code to identify functional activity associated with a carcinoid tumor.
E34.1 Other hypersecretion of intestinal hormones
E34.2 Ectopic hormone secretion, not elsewhere classified
Excludes1 ectopic ACTH syndrome (E24.3)
E34.3 Short stature due to endocrine disorder
Excludes1 achondroplastic short stature (Q77.4)
hypochondroplastic short stature (Q77.4)
nutritional short stature (E45)
pituitary short stature (E23.0)
progeria (E34.8)
renal short stature (N25.0)
Russell-Silver syndrome (Q87.19)
short-limbed stature with immunodeficiency (D82.2)
short stature (child) (R62.52)
short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
short stature NOS (R62.52)
E34.30 Short stature due to endocrine disorder, unspecified
E34.31 Constitutional short stature
Constitutional delay of growth, puberty, or maturation
E34.32 Genetic causes of short stature
E34.321 Primary insulin-like growth factor-1 (IGF-1) deficiency
Acid-labile subunit gene (IGFALS) defect
Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
Growth hormone insensitivity syndrome (GHIS)
Insulin-like growth factor 1 gene (IGF1) defect
Laron type short stature
Severe primary insulin-like growth factor-1 deficiency (SPIGFD)
Signal transducer and activator of transcription 5B gene (STAT5b) defect
E34.322 Insulin-like growth factor-1 (IGF-1) resistance
Genetic syndrome with resistance to insulin-like growth factor-1
Insulin-like growth factor-1 receptor (IGF-1R) defect
Post-insulin-like growth factor-1 receptor signaling defect
E34.328 Other genetic causes of short stature
Short stature due to ACAN gene variant
Short stature due to aggrecan deficiency
Short stature due to NPR-2 gene variant
E34.329 Unspecified genetic causes of short stature
E34.39 Other short stature due to endocrine disorder
E34.4 Constitutional tall stature
Constitutional gigantism
E34.5 Androgen insensitivity syndrome
E34.50 Androgen insensitivity syndrome, unspecified
Androgen insensitivity NOS
E34.51 Complete androgen insensitivity syndrome
Complete androgen insensitivity
de Quervain syndrome
Goldberg-Maxwell syndrome
E34.52 Partial androgen insensitivity syndrome
Partial androgen insensitivity
Reifenstein syndrome
E34.8 Other specified endocrine disorders
Pineal gland dysfunction
Progeria
Excludes2 pseudohypoparathyroidism (E20.1)
E34.9 Endocrine disorder, unspecified
Endocrine disturbance NOS
Hormone disturbance NOS
E35 Disorders of endocrine glands in diseases classified elsewhere
CodeFirst underlying disease, such as:
late congenital syphilis of thymus gland [Dubois disease] (A50.9)
UseAdditionalCode code, if applicable, to identify:
sequelae of tuberculosis of other organs (B90.8)
Excludes1 Echinococcus granulosus infection of thyroid gland (B67.3)
meningococcal hemorrhagic adrenalitis (A39.1)
syphilis of endocrine gland (A52.79)
tuberculosis of adrenal gland, except calcification (A18.7)
tuberculosis of endocrine gland NEC (A18.82)
tuberculosis of thyroid gland (A18.81)
Waterhouse-Friderichsen syndrome (A39.1)
nonPrimary Yes